Suppressive effect of the Gly389 allele of the β1-adrenergic receptor gene on the occurrence of ventricular tachycardia in dilated cardiomyopathy

被引:43
作者
Iwai, C
Akita, H
Shiga, N
Takai, E
Miyamoto, Y
Shimizu, M
Kawai, H
Takarada, A
Kajiya, T
Yokoyama, M
机构
[1] Kobe Univ, Grad Sch Med, Dept Internal Med, Div Cardiovasc & Resp Med, Kobe, Hyogo 657, Japan
[2] Kobe Univ, Grad Sch Med, Dept Internal Med, Div Gen Med Sci, Kobe, Hyogo 657, Japan
[3] Himeji Cardiovasc Ctr, Dept Cardiol, Himeji, Hyogo, Japan
关键词
beta-1-adrenergic receptor; dilated cardiomyopathy; ventricular tachycardia;
D O I
10.1253/circj.66.723
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Beta-1-adrencrgic receptor (beta1-AR) blockers reduce both the incidence of sudden death and the ventricular volume in heart failure. In vitro, the Gly389 variant of beta1-AR mediates less adenylyl cyclase activities than the Arg389 variant, so Arg389Gly polymorphism was investigated with regard to the genesis, progression, or arrhythmogenesis of dilated cardiomyopathy (DCM). Allele and genotype frequencies of the Arg389Gly polymorphism were determined in 163 DCM patients and 157 age- and sex-matched controls. There were no differences in genotype and allele frequencies between patients and controls. Echocardiograms, left ventriculograms and 24 h-Holter electrocardiograms were evaluated in the DCNI patients and none of the clinical indices, other than ventricular tachycardia (VT), differed among the 3 genotypes. The Gly389 allele was more frequent in the VT(-) group than in the VT(+) group (0.46 vs 0.24, p=0.001). In univariate analysis, the odds ratio for VT in patients carrying I or 2 copies of the Gly389 allele was 0.29 ([95% confidence interval, 0.13-0.64], p=0.002), when compared with the Arg389 homozygotes. The Gly389 variant supressed the occurrence of VT in DCM, suggesting that this allele confers a decreased risk of sudden death.
引用
收藏
页码:723 / 728
页数:6
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