Anticancer activity of polyoxomolybdate

被引：126

作者：

Yanagie, H.

Ogata, A.

Mitsui, S.

Hisa, T.

Yamase, T.

Eriguchi, M.

机构：

[1] Univ Tokyo, Adv Sci & Technol Res Ctr, Dept Intellectual Property, Project Canc Metastasis Inhibit,Meguro Ku, Tokyo 1538904, Japan

[2] Tokyo Inst Technol, Chem Res Lab, Midori Ku, Yokohama, Kanagawa 2268503, Japan

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2006年 / 60卷 / 07期

关键词：

polyoxomolybdate; cancer growth inhibition; apoptosis; redox reaction;

D O I：

10.1016/j.biopha.2006.06.018

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Anticancer polyoxomolybdates have been investigated for medical application of polyoxometalates as discrete cluster anions of metal oxides. [NH3Pri](6)[Mo7O24]center dot 3H(2)O (PM-8) has been recognized as one of significant antiturnoral polyoxomolybdates. PM-8 had shown the growth suppression against several tumors, for examples, Co-4, human colon cancer, MX-1, human breast cancer, and OAT, human lung cancer. PM-8 showed the tumor growth suppression for MKN-45 human gastric cancer in tumor bearing mice. PM-8 inhibited the cell growth of AsPC-1 which depended on the dose with showing DNA ladder formation and DNA fragmentation, and positive Hoechst staining indicating apoptosis. The ratio of apoptotic cells on flow cytometry analysis were 35%, and 57% with treatment of PM-8 after 48, and 72 h, respectively. One of the anti-tumor activity of PM-8 result from the activation of apoptotic pathway. It is thought that polyoxomolybdates will be applied as a novel antitumor agent especially against cancers which are difficult to be treated clinically. (c) 2006 Elsevier SAS. All rights reserved.

引用

页码：349 / 352

页数：4

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