Protective effects of mutant ubiquitin in transgenic mice

被引：6

作者：

Gray, DA ^{[1
]}

Tsirigotis, M ^{[1
]}

Brun, J ^{[1
]}

Tang, M ^{[1
]}

Zhang, M ^{[1
]}

Beyers, M ^{[1
]}

Woulfe, J ^{[1
]}

机构：

[1] Ottawa Hlth Res Inst, Ottawa, ON K1H 8L6, Canada

来源：

STRATEGIES FOR ENGINEERED NEGLIGIBLE SENESCENCE: WHY GENUINE CONTROL OF AGING MAY BE FORESEEABLE | 2004年 / 1019卷

关键词：

ubiquitin; mutant; transgenic; mice; life span; K48R;

D O I：

10.1196/annals.1297.035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The K48R mutant ubiquitin can exert profound in vivo protective effects against a variety of insults, including agents of direct clinical relevance. The manipulation of the ubiquitin/proteasome pathway has enormous potential for clinical benefit, and it is not unreasonable to expect that such benefits will include diseases of aging.

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收藏

页码：215 / 218

页数：4

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