A plant vacuolar protease, VPE, mediates virus-induced hypersensitive cell death

被引：473

作者：

Hatsugai, N

Kuroyanagi, M

Yamada, K

Meshi, T

Tsuda, S

Kondo, M

Nishimura, M

Hara-Nishimura, I ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Sci, Sakyo Ku, Kyoto 6068502, Japan

[2] Natl Inst Basic Biol, Dept Cell Biol, Okazaki, Aichi 4448585, Japan

[3] Grad Univ Adv Studies, Sch Life Sci, Okazaki, Aichi 4448585, Japan

[4] Natl Inst Agrobiol Sci, Tsukuba, Ibaraki 3058602, Japan

[5] Natl Agr Res Ctr, Tsukuba, Ibaraki 3058602, Japan

来源：

SCIENCE | 2004年 / 305卷 / 5685期

关键词：

D O I：

10.1126/science.1099859

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Programmed cell death (PCD) in animals depends on caspase protease activity. Plants also exhibit PCD, for example as a response to pathogens, although a plant caspase remains elusive. Here we show that vacuolar processing enzyme (VPE) is a protease essential for a virus-induced hypersensitive response that involves PCD. VPE deficiency prevented virus-induced hypersensitive cell death in tobacco plants. VPE is structurally unrelated to caspases, although VPE has a caspase-1 activity. Thus, plants have evolved a regulated cellular suicide strategy that, unlike PCD of animals, is mediated by VPE and the cellular vacuole.

引用

页码：855 / 858

页数：4

共 28 条

[1]

Angell SM, 1999, PLANT J, V20, P357, DOI 10.1046/j.1365-313X.1999.t01-1-00597.x

[2] PURIFICATION, CDNA CLONING AND CHARACTERIZATION OF PROTEINASE-B, AN ASPARAGINE-SPECIFIC ENDOPEPTIDASE FROM GERMINATING VETCH (VICIA-SATIVA L) SEEDS [J].