Predictive value of nuclear factor κB activity and plasma cytokine levels in patients with sepsis

被引:236
作者
Arnalich, F
Garcia-Palomero, E
López, J
Jiménez, M
Madero, R
Renart, J
Vazquez, JJ
Montiel, C
机构
[1] Univ Autonoma Madrid, Fac Med, Hosp La Paz, Dept Med, Madrid, Spain
[2] Univ Autonoma Madrid, Fac Med, Hosp La Paz, Dept Pharmacol, Madrid, Spain
[3] Univ Autonoma Madrid, Fac Med, Hosp La Paz, Intens Care Unit, Madrid, Spain
[4] CSIC, Inst Invest Biomed, Madrid, Spain
关键词
D O I
10.1128/IAI.68.4.1942-1945.2000
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 [免疫学];
摘要
The relationship between fluctuating cytokine concentrations in plasma and the outcome of sepsis is complex. We postulated that early measurement of the activation of nuclear factor kappa B (NF-kappa B), a transcriptional regulatory protein involved in proinflammatory cytokine expression, may help to predict the outcome of sepsis. We determined NF-kappa B activation in peripheral blood mononuclear cells of 34 patients with severe sepsis (23 survivors and 11 nonsurvivors) and serial concentrations of inflammatory cytokines (interleukin-6, interleukin-1, and tumor necrosis factor) and various endogenous antagonists in plasma. NF-kappa B activity was significantly higher in nonsurvivors and correlated strongly with the severity of illness (APACHE II score), although neither was related to the cytokine levels, Apart from NF-kappa B activity, the interleukin-1 receptor antagonist was the only cytokine tested whose level in plasma was of value in predicting mortality bs logistic regression analysis. These results underscore the prognostic value of early measurement of NF-kappa B activity in patients with severe sepsis.
引用
收藏
页码:1942 / 1945
页数:4
相关论文
共 17 条
[1]
Relationship of plasma leptin to plasma cytokines and human survival in sepsis and septic shock [J].
Arnalich, F ;
López, J ;
Codoceo, R ;
Jiménez, M ;
Madero, R ;
Montiel, C .
JOURNAL OF INFECTIOUS DISEASES, 1999, 180 (03) :908-911
[2]
Role of NF kappa B in the mortality of sepsis [J].
Bohrer, H ;
Qiu, F ;
Zimmerman, T ;
Zhang, YM ;
Jllmer, T ;
Mannel, D ;
Bottiger, BW ;
Stern, DM ;
Waldherr, R ;
Saeger, HD ;
Ziegler, R ;
Bierhaus, A ;
Martin, E ;
Nawroth, PP .
JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (05) :972-985
[3]
AMERICAN-COLLEGE OF CHEST PHYSICIANS SOCIETY OF CRITICAL CARE MEDICINE CONSENSUS CONFERENCE - DEFINITIONS FOR SEPSIS AND ORGAN FAILURE AND GUIDELINES FOR THE USE OF INNOVATIVE THERAPIES IN SEPSIS [J].
BONE, RC ;
BALK, RA ;
CERRA, FB ;
DELLINGER, RP ;
FEIN, AM ;
KNAUS, WA ;
SCHEIN, RMH ;
SIBBALD, WJ ;
ABRAMS, JH ;
BERNARD, GR ;
BIONDI, JW ;
CALVIN, JE ;
DEMLING, R ;
FAHEY, PJ ;
FISHER, CJ ;
FRANKLIN, C ;
GORELICK, KJ ;
KELLEY, MA ;
MAKI, DG ;
MARSHALL, JC ;
MERRILL, WW ;
PRIBBLE, JP ;
RACKOW, EC ;
RODELL, TC ;
SHEAGREN, JN ;
SILVER, M ;
SPRUNG, CL ;
STRAUBE, RC ;
TOBIN, MJ ;
TRENHOLME, GM ;
WAGNER, DP ;
WEBB, CD ;
WHERRY, JC ;
WIEDEMANN, HP ;
WORTEL, CH .
CRITICAL CARE MEDICINE, 1992, 20 (06) :864-874
[4]
Plasma leptin levels are increased in survivors of acute sepsis: Associated loss of diurnal rhythm in cortisol and leptin secretion [J].
Bornstein, SR ;
Licinio, J ;
Tauchnitz, R ;
Engelmann, L ;
Negrao, AB ;
Gold, P ;
Chrousos, GP .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (01) :280-283
[5]
PROGNOSTIC VALUES OF TUMOR-NECROSIS-FACTOR CACHECTIN, INTERLEUKIN-1, INTERFERON-ALPHA, AND INTERFERON-GAMMA IN THE SERUM OF PATIENTS WITH SEPTIC SHOCK [J].
CALANDRA, T ;
BAUMGARTNER, JD ;
GRAU, GE ;
WU, MM ;
LAMBERT, PH ;
SCHELLEKENS, J ;
VERHOEF, J ;
GLAUSER, MP .
JOURNAL OF INFECTIOUS DISEASES, 1990, 161 (05) :982-987
[6]
PLASMA CYTOKINE AND ENDOTOXIN LEVELS CORRELATE WITH SURVIVAL IN PATIENTS WITH THE SEPSIS SYNDROME [J].
CASEY, LC ;
BALK, RA ;
BONE, RC .
ANNALS OF INTERNAL MEDICINE, 1993, 119 (08) :771-778
[7]
Chen F, 1999, CLIN CHEM, V45, P7
[8]
Nuclear factor κB:: a pivotal role in the systemic inflammatory response syndrome and new target for therapy [J].
Christman, JW ;
Lancaster, LH ;
Blackwell, TS .
INTENSIVE CARE MEDICINE, 1998, 24 (11) :1131-1138
[9]
Sepsis and serum cytokine concentrations [J].
Damas, P ;
Canivet, JL ;
DeGroote, D ;
Vrindts, Y ;
Albert, A ;
Franchimont, P ;
Lamy, M .
CRITICAL CARE MEDICINE, 1997, 25 (03) :405-412
[10]
Plasma proinflammatory cytokine concentrations, acute physiology and chronic health evaluation (APACHE) III scores and survival in patients in an intensive care unit [J].
Friedland, JS ;
Porter, JC ;
Daryanani, S ;
Bland, JM ;
Screaton, NJ ;
Vesely, MJJ ;
Griffin, GE ;
Bennett, ED ;
Remick, DG .
CRITICAL CARE MEDICINE, 1996, 24 (11) :1775-1781