Stereochemical determination of archazolid A and B, highly potent vacuolar-type ATPase inhibitors from the myxobacterium Archangium gephyra

被引：40

作者：

Hassfeld, Jorma

Fares, Christophe

Steinmetz, Heinrich

Carlomagno, Teresa

Menche, Dirk

机构：

[1] Gesell Biotechnol Forsch mbH, Med Chem, D-38124 Braunschweig, Germany

[2] Gesell Biotechnol Forsch mbH, Umweltmikrobiol, D-38124 Braunschweig, Germany

[3] Max Planck Inst Biophys, Dept NMR Based Struct Biol, D-37077 Gottingen, Germany

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 21期

关键词：

D O I：

10.1021/ol061831y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The relative and absolute stereochemistry of the structurally unique 24-membered myxobacterial macrolides archazolid A and B, highly potent vacuolar-type ATPase (V-ATPase) inhibitors in vitro and in vivo, was determined on the basis of a combination of extensive high-field NMR studies, including J-based configuration analysis, molecular modeling, and chemical methods.

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页码：4751 / 4754

页数：4

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