Metabolic syndrome and age-related dementia: Endocrinological aspects of adaptation to aging

被引：4

作者：

Hashizume, Kiyoshi

Suzuki, Satoru

Hara, Masahiro

Komatsu, Ai

Yamashita, Koh

机构：

[1] Department of Aging Medicine and Geriatrics, Institute on Aging and Adaptation, Shinshu University

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2006年 / 127卷 / 06期

关键词：

metabolic syndrome; cognition disorder; thyroid hormone; growth hormone;

D O I：

10.1016/j.mad.2006.01.026

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Metabolic syndrome is one of the determinants of lifespan in Japan. In order to prevent the acute vascular events, intervention is recommended. However, management of patients with this syndrome increased the number of patients with cognition decline and depressive state. Endocrinological studies with human and experimental animals showed that there is a negative relationship between progression of metabolic syndrome and occurrence of mental disorders. In this review, we summarize our clinical and experimental data, and discuss on the mechanism of the metabolic syndrome prevention of progression of age-related mental disorder. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

收藏

页码：507 / 510

页数：4

相关论文

共 25 条

[1] SATURABLE TRANSPORT OF INSULIN FROM PLASMA INTO THE CENTRAL-NERVOUS-SYSTEM OF DOGS IN-VIVO - A MECHANISM FOR REGULATED INSULIN DELIVERY TO THE BRAIN [J].

BAURA, GD ;

FOSTER, DM ;

PORTE, D ;

KAHN, SE ;

BERGMAN, RN ;

COBELLI, C ;

SCHWARTZ, MW .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 92 (04) :1824-1830

[2] Metabolic syndrome as a predictor of all-cause and cardiovascular mortality in type 3 diabetes [J].

Bruno, G ;

Merletti, F ;

Biggeri, A ;

Bargero, G ;

Ferrero, S ;

Runzo, C ;

Cerai, SP ;

Pagano, G ;

Cavallo-Perin, P .

DIABETES CARE, 2004, 27 (11) :2689-2694

[3]

BU GJ, 1994, J BIOL CHEM, V269, P18521

[4] Lipoprotein receptors: Signaling functions in the brain? [J].

Cooper, JA ;

Howell, BW .

CELL, 1999, 97 (06) :671-674

[5] PROTECTIVE EFFECT OF APOLIPOPROTEIN-E TYPE-2 ALLELE FOR LATE-ONSET ALZHEIMER-DISEASE [J].

CORDER, EH ;

SAUNDERS, AM ;

RISCH, NJ ;

STRITTMATTER, WJ ;

SCHMECHEL, DE ;

GASKELL, PC ;

RIMMLER, JB ;

LOCKE, PA ;

CONNEALLY, PM ;

SCHMADER, KE ;

SMALL, GW ;

ROSES, AD ;

HAINES, JL ;

PERICAKVANCE, MA .

NATURE GENETICS, 1994, 7 (02) :180-184

[6] Functional activation of cerebral metabolism in mice with mutated thyroid hormone nuclear receptors [J].

Esaki, T ;

Suzuki, H ;

Cook, M ;

Shimoji, K ;

Cheng, SY ;

Sokoloff, L ;

Nunez, J .

ENDOCRINOLOGY, 2003, 144 (09) :4117-4122

[7] Different functions for the thyroid hormone receptors TRα and TRβ in the control of thyroid hormone production and post-natal development [J].

Gauthier, K ;

Chassande, O ;

Plateroti, M ;

Roux, JP ;

Legrand, C ;

Pain, B ;

Rousset, B ;

Weiss, R ;

Trouillas, J ;

Samarut, J .

EMBO JOURNAL, 1999, 18 (03) :623-631

[8] DEPENDENCE OF THE MITOCHONDRIAL UPTAKE OF TRIIODOTHYRONINE (T3) IN RAT-KIDNEY ON CYTOSOLIC T3-BINDING PROTEIN [J].

HASHIZUME, K ;

KOBAYASHI, M ;

MIYAMOTO, T ;

YAMAUCHI, K .

ENDOCRINOLOGY, 1986, 119 (03) :1063-1070

[9]

HASHIZUME K, 1992, J BONE MINER METAB, V10, P173

[10] Increased incidence of coronary atherosclerosis in type 2 diabetes mellitus: Mechanisms and management [J].

Hurst, RT ;

Lee, RW .

ANNALS OF INTERNAL MEDICINE, 2003, 139 (10) :824-834