Effect of cyclosporin a in a patient with refractory nephrotic syndrome associated with B chronic lymphocytic leukemia

被引：9

作者：

Eisterer, W

Neyer, U

Hilbe, W

Diem, G

Ohlschlegel, C

Ludescher, C

Thaler, J

机构：

[1] UNIV INNSBRUCK HOSP,DEPT INTERNAL MED,A-6020 INNSBRUCK,AUSTRIA

[2] GEN HOSP FELDKIRCH,DIV NEPHROL,FELDKIRCH,SWITZERLAND

[3] GEN HOSP ST GALLEN,INST PATHOL,ST GALLEN,SWITZERLAND

来源：

NEPHRON | 1996年 / 72卷 / 03期

关键词：

nephrotic syndrome; B chronic lymphocytic leukemia; membranous glomerulonephritis; cyclosporin A;

D O I：

10.1159/000188915

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

We report on a patient with an almost 20-year history of B chronic lymphocytic leukemia (B-CLL). During the last 2 years, the patient developed nephrotic syndrome (NS) due to membranous glomerulonephritis (MN), refractory to standard therapeutic regimens. Neither NS nor B-CLL responded objectively to systemic administration of two different combinations of corticosteroids and alkylating agents (chlorambucil, cyclophosphamide), Third-line therapy with cyclosporin A resulted in reduction of proteinuria and improvement of leukemia. Withdrawal of the drug led to an increase in leukocyte count.

引用

页码：468 / 471

页数：4

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