Rorγ (Rorc) is a common integration site in type B leukemogenic virus-induced T-cell lymphomas

被引：6

作者：

Broussard, DR

Lozano, MM

Dudley, JP

机构：

[1] Inst Mol & Cell Biol, Austin, TX 78712 USA

[2] Sect Microbiol & Mol Genet, Austin, TX 78712 USA

来源：

JOURNAL OF VIROLOGY | 2004年 / 78卷 / 09期

关键词：

D O I：

10.1128/JVI.78.9.4943-4946.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The retrovirus type B leukemogenic virus (TBLV) causes T-cell lymphomas in mice. We have identified the Rorgamma locus as an integration site in 19% of TBLV-induced tumors. Overexpression of one or more Rorgamma isoforms in >77% of the tumors tested may complement apoptotic effects of c-myc overexpression.

引用

收藏

页码：4943 / 4946

页数：4

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