Modelling of the strength-porosity relationship in glass-ceramic foam scaffolds for bone repair

Foam-like glass-ceramic scaffolds based on three different glass compositions (45S5 Bioglass and two other experimental formulations, CEL2 and SCNA) were produced by sponge replication and characterized from morphological, architectural and mechanical viewpoints. The relationships between porosity and compressive or tensile strength were systematically investigated and modelled, respectively, by using the theory of cellular solids mechanics or quantized fracture mechanics. Models results are in good agreement with experimental findings, which highlights the satisfactory predictive capabilities of the presented approach. The developed models could contribute to improve the rational design of porous bioceramics with custom-made properties. Knowing the scaffold recommended strength for a specific surgical need, the application of the models allows to predict the corresponding porosity, which can be tailored by varying the fabrication parameters in a controlled way so that the device fulfils the desired mechanical requirements. (C) 2013 Elsevier Ltd. All rights reserved.