Classification of osteoarthritis biomarkers:: a proposed approach

被引：288

作者：

Bauer, D. C.

Hunter, D. J.

Abramson, S. B.

Attur, M.

Corr, M.

Felson, D.

Heinegard, D.

Jordan, J. M.

Kepler, T. B.

Lane, N. E.

Saxne, T.

Tyree, B.

Kraus, V. B.

机构：

[1] Univ Calif San Francisco, Dept Med, San Francisco, CA 94107 USA

[2] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94107 USA

[3] Boston Univ, Sch Med, Clin Epidemiol Res & Training Unit, Boston, MA 02118 USA

[4] NYU, Sch Med, Dept Med, New York, NY USA

[5] NYU, Hosp Joint Dis, New York, NY USA

[6] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

[7] Lund Univ, Dept Expt Med Sci, Lund, Sweden

[8] Univ N Carolina, Dept Med, Chapel Hill, NC USA

[9] Univ N Carolina, Dept Orthoped, Chapel Hill, NC USA

[10] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

[11] Univ Calif Davis, Dept Med, Sacramento, CA 95817 USA

[12] Lund Univ, Dept Clin Sci, Lund, Sweden

[13] NIAMSD, Extramural Program, Bethesda, MD 20892 USA

来源：

OSTEOARTHRITIS AND CARTILAGE | 2006年 / 14卷 / 08期

基金：

美国国家卫生研究院;

关键词：

osteoarthritis; biomarkers; study design;

D O I：

10.1016/j.joca.2006.04.001

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Objective: Osteoarthritis (OA) biomarkers are needed by researchers and clinicians to assist in disease diagnosis and assessment of disease severity, risk of onset, and progression. As effective agents for CA are developed and tested in clinical studies, biomarkers; that reliably mirror or predict the progression or amelioration of CA will also be needed. Methods: The NIH-funded CA Biomarkers Network is a multidisciplinary group interested in the development and validation of CA biomarkers. This review summarizes our efforts to characterize and classify CA biomarkers. Results: We propose the "BIPED" biomarker classification (which stands for Burden of Disease, Investigative, Prognostic, Efficacy of Intervention and Diagnostic), and offer suggestions on optimal study design and analytic methods for use in CA investigations. Conclusion. The BIPED classification provides specific biomarker definitions with the goal of improving our ability to develop and analyze OA biomarkers, and to communicate these advances within a common framework. (C) 2006 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

引用

页码：723 / 727

页数：5

共 23 条

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