Nucleophosmin and cancer

被引：672

作者：

Grisendi, Silvia

Mecucci, Cristina

Falini, Brunangelo

Pandolfi, Pier Paolo

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Pathol, Canc Biol & Genet Program, New York, NY 10021 USA

[2] Monteluce Policlin, Inst Haematol, Perugia, Italy

来源：

NATURE REVIEWS CANCER | 2006年 / 6卷 / 07期

关键词：

D O I：

10.1038/nrc1885

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

NPM1 is a crucial gene to consider in the context of the genetics and biology of cancer. NPM1 is frequently overexpressed, mutated, rearranged and deleted in human cancer. Traditionally regarded as a tumour marker and a putative proto-oncogene, it has now also been attributed with tumour-suppressor functions. Therefore, NPM can contribute to oncogenesis through many mechanisms. The aim of this review is to analyse the role of NPM in cancer, and examine how deregulated NPM activity (either gain or loss of function) can contribute to tumorigenesis.

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收藏

页码：493 / 505

页数：13

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