Rethinking T cell immunity in oropharyngeal candidiasis

被引：27

作者：

Pirofski, Liise-anne ^{[1
,2
]}

Casadevall, Arturo ^{[1
,2
]}

机构：

[1] Albert Einstein Coll Med, Coll Med, Dept Med, Bronx, NY 10467 USA

[2] Albert Einstein Coll Med, Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2009年 / 206卷 / 02期

基金：

美国国家卫生研究院;

关键词：

VULVO-VAGINAL CANDIDIASIS; VIRUS-INFECTED WOMEN; HOST-DEFENSE; INFLAMMATORY RESPONSES; KLEBSIELLA-PNEUMONIAE; ORAL CANDIDIASIS; IL-23; HAART; COLONIZATION; RESISTANCE;

D O I：

10.1084/jem.20090093

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The disproportionate increase in oropharyngeal candidiasis (OPC) compared with systemic and vaginal candidiasis in female patients with AIDS has been a paradox for almost three decades. New data now show that severe OPC develops in Th17-deficient mice, but not Th1-deficient mice, implicating Th17-induced effector molecules in resistance to oral disease. These findings clarify and extend our current thinking about how CD4 T cell deficiency influences susceptibility to OPC.

引用

页码：269 / 273

页数：5

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