The zebrafish as a model system for assessing the reinforcing properties of drugs of abuse

被引：173

作者：

Ninkovic, Jovica

Bally-Cuif, Laure

机构：

[1] Tech Univ Munich, Inst Virol, Zebrafish Neurogenet Jr Res Grp, D-81675 Munich, Germany

[2] GSF, Natl Res Ctr Environm & Hlth, Dept Zebrafish Neurogenet, Inst Dev Genet, D-85764 Neuherberg, Germany

来源：

METHODS | 2006年 / 39卷 / 03期

关键词：

zebrafish; addiction; conditioned place preference (CPP); aversion; learning and memory; D-amphetamine; behavior;

D O I：

10.1016/j.ymeth.2005.12.007

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent reports make use of the zebrafish to study complex behavior such as addiction, anxiety, or learning and memory. We have established reliable tests and appropriate controls to measure these behavioral parameters in the zebrafish adult. Our assays are robust enough to permit the detection of dominant mutations affecting drug-induced reward, and therefore can be used in forward genetic screens. We provide the reader with the technical details of these tests, as well as their appropriate and crucial, although often overlooked, control assays. In particular, our results make it possible to use the zebrafish as a promising model to identify new genetic components of the reward pathway, or other measurable behaviors. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：262 / 274

页数：13

共 41 条

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