Prognosis of limited resection versus lobectomy in elderly patients with invasive lung adenocarcinoma with tumor size less than or equal to 2 cm

被引：11

作者：

Chen, Tianxiang ^{[1
,2
]}

Luo, Jizhuang ^{[3
]}

Wang, Rui ^{[3
]}

Gu, Haiyong ^{[3
]}

Gu, Yu ^{[4
]}

Huang, Qingyuan ^{[3
]}

Wang, Yiyang ^{[3
]}

Zheng, Jiajie ^{[3
]}

Yang, Yunhai ^{[1
]}

Zhao, Heng ^{[3
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Shanghai Lung Canc Ctr, Shanghai 200030, Peoples R China

[2] Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325000, Peoples R China

[3] Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Dept Thorac Surg, 241 West Huai Hai Rd, Shanghai 200030, Peoples R China

[4] Fudan Univ, Shanghai Canc Ctr, Dept Radiat Oncol, Shanghai 200030, Peoples R China

来源：

JOURNAL OF THORACIC DISEASE | 2018年 / 10卷 / 04期

基金：

美国国家科学基金会;

关键词：

Invasive lung adenocarcinoma; stage I; resection; lobectomy; wedge resection; ADJUVANT CHEMOTHERAPY; CANCER STATISTICS; STAGE IB; CLASSIFICATION; MICROPAPILLARY; IMPACT; SEGMENTECTOMY; PATTERNS; REVISION; SUBTYPES;

D O I：

10.21037/jtd.2018.04.47

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

100201 [内科学];

摘要：

Background: This study aimed to evaluate the prognostic difference between limited resection and lobectomy among elderly patients with small size lung adenocarcinoma. Methods: A total of 666 patients >65 years old with stage I lung adenocarcinoma and tumor size <= 2 cm were included. The patient survival was evaluated by disease-free survival (DFS) and overall survival (OS). Results: No DFS or OS advantage was found between the lobectomy and wedge resection groups when tumor sizes were <= 1 cm ( DFS, P=0.112; OS, P=0.294). The wedge resection group had a significantly worse OS (P=0.041) than that in the lobectomy group when tumor sizes were >1 cm and <= 2 cm. Conclusions: We conclude that wedge resection may be a reasonable surgical choice for elderly patients with tumor sizes <= 1 cm.

引用

页码：2231 / 2239

页数：9

共 30 条

[1]

[Anonymous], SCI REP UK

[2]

Clinical impacts of a micropapillary pattern in lung adenocarcinoma: a review [J].

Cao, Ying ;

Zhu, Li-Zhen ;

Jiang, Meng-Jie ;

Yuan, Ying .

ONCOTARGETS AND THERAPY, 2015, 9 :149-158

[3]

Cancer Statistics in China, 2015 [J].

Chen, Wanqing ;

Zheng, Rongshou ;

Baade, Peter D. ;

Zhang, Siwei ;

Zeng, Hongmei ;

Bray, Freddie ;

Jemal, Ahmedin ;

Yu, Xue Qin ;

He, Jie .

CA-A CANCER JOURNAL FOR CLINICIANS, 2016, 66 (02) :115-132

[4]

American College of Chest Physicians and Society of Thoracic Surgeons Consensus Statement for Evaluation and Management for High-Risk Patients With Stage I Non-small Cell Lung Cancer [J].

Donington, Jessica ;

Ferguson, Mark ;

Mazzone, Peter ;

Handy, John, Jr. ;

Schuchert, Matthew ;

Fernando, Hiran ;

Loo, Billy, Jr. ;

Lanuti, Michael ;

de Hoyos, Alberto ;

Detterbeck, Frank ;

Pennathur, Arjun ;

Howington, John ;

Landreneau, Rodney ;

Silvestri, Gerard .

CHEST, 2012, 142 (06) :1620-1635

[5]

Non-Small Cell Lung Cancer, Version 6.2015 Featured Updates to the NCCN Guidelines [J].

Ettinger, David S. ;

Wood, Douglas E. ;

Akerley, Wallace ;

Bazhenova, Lyudmila A. ;

Borghaei, Hossein ;

Camidge, David Ross ;

Cheney, Richard T. ;

Chirieac, Lucian R. ;

D'Amico, Thomas A. ;

Demmy, Todd L. ;

Dilling, Thomas J. ;

Dobelbower, M. Chris ;

Govindan, Ramaswamy ;

Grannis, Frederic W., Jr. ;

Horn, Leora ;

Jahan, Thierry M. ;

Komaki, Ritsuko ;

Krug, Lee M. ;

Lackner, Rudy P. ;

Lanuti, Michael ;

Lilenbaum, Rogerio ;

Lin, Jules ;

Loo, Billy W., Jr. ;

Martins, Renato ;

Otterson, Gregory A. ;

Patel, Jyoti D. ;

Pisters, Katherine M. ;

Reckamp, Karen ;

Riely, Gregory J. ;

Rohren, Eric ;

Schild, Steven E. ;

Shapiro, Theresa A. ;

Swanson, Scott J. ;

Tauer, Kurt ;

Yang, Stephen C. ;

Gregory, Kristina ;

Hughes, Miranda .

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2015, 13 (05) :515-524

[6]

Ginsberg RJ, 1995, Ann Thorac Surg, V60, P622, DOI [10.1016/0003-4975, 10.1016/0003-4975(95)00537-u]

[7]

The IASLC lung cancer staging project: Proposals for the revision of he TNM stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours [J].

Goldstraw, Peter ;

Crowley, John ;

Chansky, Kari ;

Giroux, Dorothy J. ;

Groome, Patti A. ;

Rami-Porta, Ramon ;

Postmus, Pieter E. ;

Rusch, Valerie ;

Sobin, Leslie .

JOURNAL OF THORACIC ONCOLOGY, 2007, 2 (08) :706-714

[8]

RANDOMIZED TRIAL OF LOBECTOMY VERSUS LIMITED RESECTION FOR T1 N0 NON-SMALL-CELL LUNG-CANCER [J].

HOLMES, CE ;

RUCKDESCHEL, JC ;

JOHNSTON, M ;

THOMAS, PA ;

DESLAURIERS, J ;

GROVER, FL ;

HILL, LD ;

FELD, R ;

GINSBERG, RJ ;

MOUNTAIN, CF ;

DZUIBAN, S ;

KIELY, M ;

MCKNEALLY, MF ;

MOORES, DWO ;

RAMNES, C ;

WAGNER, H ;

BUNN, P ;

CHU, H ;

DIENHART, D ;

HAZUKA, M ;

KINZIE, J ;

SORENSEN, J ;

VANCE, V ;

BRAUN, T ;

HOPEMAN, A ;

KANE, M ;

RUSS, P ;

WHITMAN, GJR ;

FALL, SM ;

HANSEN, DP ;

HENDERSON, RH ;

MONCRIEF, CL ;

PAULING, F ;

SIMS, J ;

TELL, D ;

WISELYCARR, S ;

ABERNATHY, CM ;

CLARK, DA ;

MCCROSKEY, B ;

MOORE, G ;

MOORE, F ;

MYERS, A ;

WHITE, M ;

BROOKS, RJ ;

BULL, M ;

JOHNSON, FB ;

NEIMYR, M ;

PAQUETTE, FR ;

SACCOMANNO, G ;

LAD, T .

ANNALS OF THORACIC SURGERY, 1995, 60 (03) :615-622

[9]

Adjuvant Chemotherapy Improves the Probability of Freedom From Recurrence in Patients With Resected Stage IB Lung Adenocarcinoma [J].

Hung, Jung-Jyh ;

Wu, Yu-Chung ;

Chou, Teh-Ying ;

Jeng, Wen-Juei ;

Yeh, Yi-Chen ;

Hsu, Wen-Hu .

ANNALS OF THORACIC SURGERY, 2016, 101 (04) :1346-1353

[10]

Segmental resection spares pulmonary function in patients with stage I lung cancer [J].

Keenan, RJ ;

Landreneau, RJ ;

Maley, RH ;

Singh, D ;

Macherey, R ;

Bartley, S ;

Santucci, T .

ANNALS OF THORACIC SURGERY, 2004, 78 (01) :228-233

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