Coated-Platelet Levels Are Low in Patients With Spontaneous Intracerebral Hemorrhage

被引：37

作者：

Prodan, Calin I. ^{[1
,3
]}

Vincent, Andrea S.

Padmanabhan, Rajiv ^{[1
]}

Dale, George L. ^{[2
]}

机构：

[1] Univ Oklahoma, Dept Neurol, Hlth Sci Ctr, Ctr Study Human Operator Performance, Norman, OK 73019 USA

[2] Univ Oklahoma, Dept Med, Hlth Sci Ctr, Ctr Study Human Operator Performance, Norman, OK 73019 USA

[3] Vet Affairs Med Ctr, Oklahoma City, OK 73104 USA

来源：

STROKE | 2009年 / 40卷 / 07期

关键词：

platelets; hemorrhage; intracerebral; LACUNAR STROKE; SEROTONIN; SURFACE;

D O I：

10.1161/STROKEAHA.109.549014

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose-Coated-platelets are a subset of platelets with high procoagulant potential observed on dual agonist stimulation with collagen and thrombin. Failure to produce coated-platelets in animals results in a bleeding diathesis. With this background, we undertook a pilot study to investigate coated-platelet production in patients with spontaneous intracerebral hemorrhage (SICH). Methods-Coated-platelet levels were determined in 26 patients with a diagnosis of SICH and 52 controls. Results-The patient population had significantly lower coated-platelet levels than the controls (mean +/- SD, 24.8 +/- 9.7% versus 32.9 +/- 12.6%, P = 0.0035). Conclusions-Decreased coated-platelet synthesis may be linked to the mechanisms involved in the events leading to SICH. (Stroke. 2009; 40: 2578-2580.)

引用

页码：2578 / 2580

页数：3

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