Glucose biosensor based on multiwalled carbon nanotubes grown directly on Si

被引：49

作者：

Chen, Yan-Shi ^{[1
]}

Huang, Jin-Hua ^{[1
]}

Chuang, Chia-Chih ^{[1
]}

机构：

[1] Natl Tsing Hua Univ, Dept Mat Sci & Engn, Hsinchu 300, Taiwan

来源：

CARBON | 2009年 / 47卷 / 13期

关键词：

SOL-GEL; AMPEROMETRIC BIOSENSORS; ELECTROCHEMICAL SENSORS; ELECTRON-TRANSFER; VAPOR-DEPOSITION; OXIDASE; ENZYME; SOLUBILIZATION; NAFION; IMMOBILIZATION;

D O I：

10.1016/j.carbon.2009.07.029

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

An amperometric biosensor based on covalent immobilization of glucose oxidase (GOx) on multiwalled carbon nanotubes (MWCNTs) with potassium ferricyanide as the redox mediator was developed. The MWCNTs were grown directly on a layered structure of Co/Ti/Cr on a SiO2/Si substrate by microwave-heated chemical vapor deposition. The mediator helps to shuttle the electrons between the immobilized GOx and the MWCNT electrode, therefore operating at a potential of 0.25 V vs. the saturated calomel electrode. This potential precludes the interfering compounds from oxidization. The sensitivity of biosensors to glucose was found to depend on the acid pretreatment and GOx reaction times. The steady-state response of the optimized biosensor exhibits a sensitivity of 20.6 mu A mM(-1) cm(-2), a linear range of up to 8 mM, and a response time of <5 s. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：3106 / 3112

页数：7

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