Synthesis and anticancer evaluation of vitamin K3 analogues

被引：37

作者：

Chen, CP ^{[1
]}

Liu, YZ

Shia, KS

Tseng, HY

机构：

[1] Natl Dong Hwa Univ, Dept Chem, Shoufeng 974, Hualien, Taiwan

[2] Natl Hlth Res Inst, Div Biotechnol & Pharmaceut Res, His Chih Cheng 221, Taipei Hsien, Taiwan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 19期

关键词：

D O I：

10.1016/S0960-894X(02)00532-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel vitamin K-3 analogues were synthesized and evaluated for their anticancer activity. Compound 6, 9, 10, 11, 14, and (+/-)15 demonstrated a strong inhibitory activity against the tumor cells of A-549, Hep G2, MCF7, MES-SA, MES-SA/Dx5, MKN45, SW-480, and TW-039. Compound (+/-)15 displayed potent tumor cell cytotoxicity, and compound 14 selectively affected MCF7, even though it did not influence normal cells Detroit551 and WI-38. Compound (+/-)15 inhibited MES-SA and MES-SA/Dx5, and this specific result shows that compound (+/-)15 may become a good anticancer drug candidate. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2729 / 2732

页数：4

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