Association between longer duration of HIV-suppressive therapy and partial recovery of the Vγ2 T cell receptor repertoire

被引：33

作者：

Bordon, J ^{[1
]}

Evans, PS ^{[1
]}

Propp, N ^{[1
]}

Davis, CE ^{[1
]}

Redfield, RR ^{[1
]}

Pauza, CD ^{[1
]}

机构：

[1] Univ Maryland, Inst Human Virol, Inst Biotechnol, Baltimore, MD 21201 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2004年 / 189卷 / 08期

关键词：

D O I：

10.1086/382961

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human immunodeficiency virus (HIV) infection alters the function and repertoire of peripheral blood gammadelta T cells expressing the Vgamma2/Vdelta2 T cell receptor (TCR). A cross-sectional comparison of the Vgamma2 TCR repertoire was performed for 56 HIV-infected subjects, 51 of whom were receiving highly active antiretroviral therapy ( HAART), to measure changes in the Vgamma2 TCR repertoire. Longer durations of HAART were associated with partial recovery of the normal TCR repertoire, and recovery was greatest in subjects with complete virus suppression. Changes in the Vgamma2 TCR repertoire are sensitive measures for the effects of HAART and of residual HIV replication.

引用

页码：1482 / 1486

页数：5

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