An outbreak of influenza in a residential drug-rehabilitation community

被引:17
作者
Boschini, Antonio
Longo, Benedetta
Caselli, Francesca
Begnini, Marco
De Maria, Cesare
Ansaldi, Filippo
Durando, Paolo
Icardi, Giancarlo
Rezza, Giovanni
机构
[1] Ist Super Sanita, Epidemiol Unit, Dept Infect Dis, I-00161 Rome, Italy
[2] Univ Genoa, Dept Hlth Sci, Genoa, Italy
[3] San Patrignano Community, Med Ctr, Rimini, Italy
关键词
influenza; injecting drug users; HIV; outbreak investigation; risk factors;
D O I
10.1002/jmv.20684
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Influenza outbreaks can be difficult to control in confined settings where high-risk individuals are concentrated. Following the occurrence of a large number of cases of influenza-like illness in a rehabilitation community for drug users, between February and March 2004, surveillance activities were implemented. Attack rates of influenza-like illness were calculated, and risk factors for the development of disease and complications were evaluated through the use of relative risks (RR) with 95% confidence intervals (CI). Nasal-pharyngeal samples were collected for virological studies. Of 1,310 persons who were living in the community, 209 were diagnosed with influenza-like illness: the attack rate (15.9% overall) was higher for HIV-infected persons (RR: 1.77, 95% CI: 1.32-2.37), older individuals, and dormitory residents. HIVinfected participants were also more likely to develop complications compared with HIV-uninfected persons diagnosed with influenza-like illness (RR: 5.13, 95% CI: 2.52-10.20). The outbreak was attributable to Christchurch-like influenza A strains. Vaccination was ineffective because of the mismatch between wild and vaccine strains.
引用
收藏
页码:1218 / 1222
页数:5
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