Mechanistic Studies of Gd3+-Based MRI Contrast Agents for Zn2+ Detection: Towards Rational Design

被引：29

作者：

Bonnet, Celia S. ^{[1
]}

Caille, Fabien ^{[1
,2
]}

Pallier, Agnes ^{[1
]}

Morfin, Jean-Francois ^{[1
]}

Petoud, Stephane ^{[1
]}

Suzenet, Franck ^{[2
]}

Toth, Eva ^{[1
]}

机构：

[1] CNRS, Ctr Biophys Mol, F-45071 Orleans, France

[2] Univ Orleans, CNRS, UMR 7311, Inst Chim Organ & Analyt, F-45067 Orleans, France

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 35期

关键词：

lanthanides; NMR spectroscopy; relaxation; sensors; zinc; ELECTRONIC RELAXATION; GD(III) COMPLEX; WATER EXCHANGE; METAL-IONS; O-17; NMR; IN-VIVO; ZINC; GADOLINIUM; RELAXIVITY; LUMINESCENCE;

D O I：

10.1002/chem.201403043

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A series of novel pyridine-based Gd3+ complexes have been prepared and studied as potential MRI contrast agents for Zn2+ detection. By independent assessment of molecular parameters affecting relaxivity, we could interpret the relaxivity changes observed upon Zn2+ binding in terms of variations of the rotational motion.

引用

页码：10959 / 10969

页数：11

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