The role of interleukin-1β in the pathogenesis of multiple myeloma

被引：68

作者：

Lust, JA ^{[1
]}

Donovan, KA

机构：

[1] Mayo Clin & Mayo Fdn, Div Hematol & Internal Med, Rochester, MN 55905 USA

[2] Mayo Clin & Mayo Grad Sch Med, Rochester, MN 55901 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 1999年 / 13卷 / 06期

关键词：

D O I：

10.1016/S0889-8588(05)70115-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this article, the role of interleukin-1 beta (IL-1 beta) in the clinical progression of monoclonal gammopathy of undetermined significance (MGUS) to active myeloma is reviewed. IL-1 beta has potent osteoclast activating factor activity, can increase the expression of adhesion molecules, and can induce paracrine IL-6 production. These biologic effects of IL-1 beta closely parallel several of the clinical features of human myeloma. A greater understanding of the biology of monoclonal gammopathies may provide a rational basis for future research and the development of novel biologic therapies to treat myeloma in the future.

引用

页码：1117 / +

页数：10

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