Cytotoxic monotetrahydrofuran acetogenins from Disepalum plagioneurum

被引：8

作者：

Eparvier, Veronique

Nguyen, Van Hung

Thoison, Odile

Martin, Marie-Therese

Sevenet, Thierry

Gueritte, Francoise

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

[2] VAST, Inst Chem, Hanoi, Vietnam

来源：

JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 09期

关键词：

D O I：

10.1021/np060168j

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The known plagionicin A ( 1) and eight new monotetrahydrofuran acetogenins, plagionicins B-D (2-4) and plagioneurins A-E (5-9), were isolated from the leaves of Disepalum plagioneurum by bioassay-guided purification. The structures of the new compounds were elucidated by spectroscopic methods. The new monotetrahydrofuran (mono-THF) acetogenins exhibited significant in vitro cytotoxicity against the KB cancer cell line, with IC50 values in the nanomolar range.

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页码：1289 / 1294

页数：6

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