Bdellovibrio as therapeutic agents:: a predatory renaissance?

被引：145

作者：

Sockett, RE ^{[1
]}

Lambert, C

机构：

[1] Univ Nottingham, Sch Biol, Inst Genet, Nottingham NG7 2UH, England

[2] Univ Nottingham, Sch Med, Nottingham NG7 2UH, England

来源：

NATURE REVIEWS MICROBIOLOGY | 2004年 / 2卷 / 08期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1038/nrmicro959

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Bdellovibrio are predatory bacteria that invade the periplasm of other Gram-negative bacteria where they undergo a complex developmental cycle that culminates in killing of the prey cell. Their intracellular niche allows Bdellovibrio to feed without competition and their lytic action can rapidly reduce bacterial populations, including pathogens, making these predatory bacteria interesting potential candidates for therapeutic applications. With the complete genome sequence for one Bdellovibrio strain now available, researchers now have an opportunity to evaluate the therapeutic potential of these predatory bacteria.

引用

页码：669 / 675

页数：7

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