Treatment of inflammatory bowel disease with azathioprine and 6-mercaptopurine

被引：65

作者：

Su, CY ^{[1
]}

Lichtenstein, GR ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Div Gastroenterol, Dept Med, Philadelphia, PA 19104 USA

来源：

GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2004年 / 33卷 / 02期

关键词：

D O I：

10.1016/j.gtc.2004.02.004

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

6-Mercaptopurine and azathioprine have become important therapeutic options for patients with inflammatory bowel disease (IBD). Although accumulating data in the literature have supported the use of these immunomodulators; in the management of IBD, marked variation exists in the pattern of clinical practice regarding azathioprine or 6-mercaptopurine therapy in patients with IBD. This article provides a critical review of the data on the clinical efficacy and toxicities of 6-mercaptopurine and azathioprine in the management of IBD. Emerging literature on the potential application of pharmacogenetic testing and metabolite monitoring are also discussed.

引用

页码：209 / +

页数：27

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