Carbohydrate based vaccines

被引：59

作者：

Vliegenthart, Johannes F. G. ^{[1
]}

机构：

[1] Univ Utrecht, Bijvoet Ctr, Div Bioorgan Chem, NL-3584 CH Utrecht, Netherlands

来源：

FEBS LETTERS | 2006年 / 580卷 / 12期

关键词：

glycoconjugate vaccines; cell surface antigens; infections; cancer; oligosaccharide synthesis;

D O I：

10.1016/j.febslet.2006.03.053

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the past decades, a gradual increase in the resistance to antibiotics has been observed, leading to a serious thread for successful treatment of bacterial infections. This feature in addition to difficulties in developing adequate drugs against (tropical) diseases caused by parasites has stimulated the interest in vaccines to prevent infections. In principle, various types of cell surface epitopes, characteristic for the invading organism or related to aberrant growth of cells, can be applied to develop vaccines. The progress in establishing the structure of carbohydrate immuno-determinants in conjunction with improvements in carbohydrate synthesis has rendered it feasible to develop new generations of carbohydrate-based vaccines. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2945 / 2950

页数：6

共 47 条

[1]

Avery O T, 1931, J Exp Med, V54, P437, DOI 10.1084/jem.54.3.437

[2] Synthetic polysaccharide type 3-related di-, tri-, and tetrasaccharide-CRM197 conjugates induce protection against Streptococcus pneumoniae type 3 in mice [J].

Benaissa-Trouw, B ;

Lefeber, DJ ;

Kamerling, JP ;

Vliegenthart, JFG ;

Kraaijeveld, K ;

Snippe, H .

INFECTION AND IMMUNITY, 2001, 69 (07) :4698-4701

[3] Dendrimers in drug research [J].

Boas, U ;

Heegaard, PMH .

CHEMICAL SOCIETY REVIEWS, 2004, 33 (01) :43-63

[4] Immunotherapy of advanced breast cancer with a heterophilic ganglioside (NeuGcGM3) cancer vaccine [J].

Carr, A ;

Rodríguez, E ;

Arango, MD ;

Camacho, R ;

Osorio, M ;

Gabri, M ;

Carrillo, G ;

Valdés, Z ;

Bebelagua, Y ;

Pérez, R ;

Fernández, LE .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (06) :1015-1021

[5] A purified GM3 ganglioside conjugated vaccine induces specific, adjuvant-dependent and non-transient antitumour activity against B16 mouse melanoma in vitro and in vivo [J].

Carr, A ;

Mazorra, Z ;

Alonso, DF ;

Mesa, C ;

Valiente, O ;

Gomez, DE ;

Perez, R ;

Fernandez, LE .

MELANOMA RESEARCH, 2001, 11 (03) :219-227

[6]

Chapman PB, 2000, CLIN CANCER RES, V6, P4658

[7] A strategy for rational design of fully synthetic glycopeptide conjugate vaccines [J].

Chong, P ;

Chan, N ;

Kandil, A ;

Tripet, B ;

James, O ;

Yang, YP ;

Shi, SP ;

Klein, M .

INFECTION AND IMMUNITY, 1997, 65 (12) :4918-4925

[8] Polysaccharide processing and presentation by the MHCII pathway [J].

Cobb, BA ;

Wang, O ;

Tzianabos, AO ;

Kasper, DL .

CELL, 2004, 117 (05) :677-687

[9] Roles of glycosylphosphatidylinositols of Toxoplasma gondii -: Induction of tumor necrosis factor-α production in macrophages [J].

Debierre-Grockiego, F ;

Azzouz, N ;

Schmidt, J ;

Dubremetz, JF ;

Geyer, H ;

Geyer, R ;

Weingart, R ;

Schmidt, RR ;

Schwarz, RT .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (35) :32987-32993

[10] Breast cancer vaccines: maximizing cancer treatment by tapping into host immunity [J].

Emens, LA ;

Reilly, RT ;

Jaffee, EM .

← 1 2 3 4 5 →