Rapid prefrontal-hippocampal habituation to novel events

被引:168
作者
Yamaguchi, S
Hale, LA
D'Esposito, M
Knight, RT
机构
[1] Shimane Univ, Sch Med, Dept Neurol, Izumo, Shimane 6938501, Japan
[2] Univ Calif Berkeley, Henry H Wheeler Jr Brain Imaging Ctr, Dept Psychol, Berkeley, CA 94720 USA
[3] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA
关键词
orienting response; novelty detection; event-related fMRI; single trial analysis; visual attention; limbic system;
D O I
10.1523/JNEUROSCI.4587-03.2004
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Unexpected novel events generate an orienting response that plays an important role in some forms of learning and memory. The orienting response involuntarily captures attention and rapidly habituates as events become familiarized. Although evidence from patients with focal lesions and scalp and intracranial event-related brain potential recordings supports the involvement of a distributed neural network involving association cortex and the limbic system in novelty detection, the key neural substrates and temporal dynamics have not been defined. While subjects performed a bi-field visual-selective attention task with random novel stimuli embedded in either attended or unattended visual fields, we measured rapid changes of regional blood oxygenation level-dependent (BOLD) signal to target and novel stimuli using single-trial analysis of event-related functional magnetic resonance imaging with a 4T scanner. Habituation was quantified by serial BOLD signal changes during the first 10 novel stimuli for each subject. Novel stimuli activated the bilateral superior/middle frontal gyrus, temporal-parietal junction, superior parietal lobe, cingulate gyrus, hippocampus, and fusiform gyrus. The superior/middle frontal gyrus and hippocampus showed significant reduction of BOLD signal during the first few novel stimuli, whereas the signals in the fusiform and cingulate gyrus were constant. Prefrontal and hippocampal responses to attended and unattended novel stimuli were comparably habituated. These results, and previous data from lesion studies, support the view that prefrontal and hippocampal regions are involved in rapid automatic detection and habituation to unexpected environmental events and are key elements of the orienting response in humans.
引用
收藏
页码:5356 / 5363
页数:8
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