Development of leiomyomas on the uterine remnants of two women with Mayer-Rokitansky-Kuster-Hauser syndrome

Objective: To describe two cases of leiomyoma development in patients with Mayer-Rokitansky-Kuster-Hauser syndrome (MRKH syndrome). Design: Case report. Setting: Second Department of Obstetrics and Gynecology, University of Athens, Aretaieion Hospital, Athens, Greece. Patient(s): A 42-year-old woman with MRKH syndrome presented with lower abdominal pain, and a 38-year-old woman with MRKH syndrome presented with an asymptomatic left adnexal mass. Interventions(s): Clinical examination, transabdominal ultrasonography, IV urography, laparoscopy. Main Outcome Measure(s): Ultrasound. Result(s): In both cases, laparoscopy revealed a leiomyoma originating from the left uterine remnant. The leiomyomas and the adjacent uterine remnants were laparoscopically excised. Conclusion(s): In rare cases, leiomyomas can originate from the fibromuscular tissue of uterine remnants in patients with MRKH syndrome.