Meta-analysis of autologous bone marrow transplantation versus chemotherapy in adult patients with acute myeloid leukemia in first remission

被引：41

作者：

Levi, I ^{[1
]}

Grotto, I

Yerushalmi, R

Ben-Bassat, I

Shpilberg, O

机构：

[1] Soroka Univ Med Ctr, Inst Hematol, IL-84101 Beer Sheva, Israel

[2] Tel Aviv Univ, Chaim Sheba Med Ctr, IL-52621 Tel Hashomer, Israel

来源：

LEUKEMIA RESEARCH | 2004年 / 28卷 / 06期

关键词：

acute myeloid leukemia; autologous bone marrow transplantation; meta-analysis;

D O I：

10.1016/j.leukres.2003.10.029

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

In the present study, we have conducted a meta-analysis comparing autologous bone marrow transplantation (ABMT) and intensive chemotherapy in adult acute myeloid leukemia (AML) patients in first remission. Combined results of the six appropriate randomised controlled studies indicate that ABMT had no advantage over chemotherapy or no further treatment concerning death rate (overall rate ratio (RR)-0.95, 95% CL 0.81-1.11), while was superior to chemotherapy concerning event rate (overall RR-0.82, 95% Cl, 0.71-0.94). In conclusion, ABMT did not improve survival but it improved event-free survival (EFS) when compared with chemotherapy or no further treatment in patients with AML in first complete remission. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：605 / 612

页数：8

共 41 条

[1]

ABRAMSON JC, 1999, COMPUTER PROGRAMS EP

[2]

Randomised comparison of addition of autologous bone-marrow transplantation to intensive chemotherapy for acute myeloid leukaemia in first remission: results of MRC AML 10 trial [J].

Burnett, AK ;

Goldstone, AH ;

Stevens, RMF ;

Hann, IM ;

Rees, JKH ;

Gray, RG ;

Wheatley, K .

LANCET, 1998, 351 (9104) :700-708

[3]

AUTOLOGOUS BONE-MARROW TRANSPLANT IN ACUTE MYELOID-LEUKEMIA IN 1ST REMISSION [J].

CASSILETH, PA ;

ANDERSEN, J ;

LAZARUS, HM ;

COLVIN, OM ;

BENNETT, JM ;

STADTMAUER, EA ;

KAIZER, H ;

WEINER, RS ;

EDELSTEIN, M ;

OKEN, MM .

JOURNAL OF CLINICAL ONCOLOGY, 1993, 11 (02) :314-319

[4]

Chemotherapy compared with autologous or allogeneic bone marrow transplantation in the management of acute myeloid leukemia in first remission [J].

Cassileth, PA ;

Harrington, DP ;

Appelbaum, FR ;

Lazarus, HM ;

Rowe, JM ;

Paietta, E ;

Willman, C ;

Hurd, DD ;

Bennett, JM ;

Blume, KG ;

Head, DR ;

Wiernik, PH .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (23) :1649-1656

[5]

CASSILETH PA, 1992, BLOOD, V79, P1924

[6]

A METHOD FOR ASSESSING THE QUALITY OF A RANDOMIZED CONTROL TRIAL [J].

CHALMERS, TC ;

SMITH, H ;

BLACKBURN, B ;

SILVERMAN, B ;

SCHROEDER, B ;

REITMAN, D ;

AMBROZ, A .

CONTROLLED CLINICAL TRIALS, 1981, 2 (01) :31-49

[7]

CHAO NJ, 1993, BLOOD, V81, P319

[8]

METAANALYSIS IN CLINICAL-TRIALS [J].

DERSIMONIAN, R ;

LAIRD, N .

CONTROLLED CLINICAL TRIALS, 1986, 7 (03) :177-188

[9]

INCORPORATING VARIATIONS IN THE QUALITY OF INDIVIDUAL RANDOMIZED TRIALS INTO METAANALYSIS [J].

DETSKY, AS ;

NAYLOR, CD ;

OROURKE, K ;

MCGEER, AJ ;

LABBE, KA .

JOURNAL OF CLINICAL EPIDEMIOLOGY, 1992, 45 (03) :255-265

[10]

DEXTER TM, 1994, BLOOD, V84, P673

← 1 2 3 4 5 →