Estrogens and neuroprotection

被引:156
作者
Wise, PM [1 ]
机构
[1] Univ Calif Davis, Div Biol Sci, Davis, CA 95616 USA
关键词
D O I
10.1016/S1043-2760(02)00611-2
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In recent years, we have become increasingly aware that estrogen is a gonadal hormone that exerts diverse non-reproductive actions on multiple organs and in multiple physiological systems. Amongst these, estrogen has profound effects on plasticity and cell survival of the adult brain. Over the past 100 years, the lifespan of women has increased to >80 years, but the age of the menopause has remained fixed. Women are therefore living an ever-increasing proportion of their lives in a hypoestrogenic, postmenopausal state, which could contribute to an increased risk of cognitive dysfunction and a variety of neurodegenerative diseases. Recent experiments emphasize the importance of apoptosis as a mechanism of cell death after brain injury induced by global ischemia, and indicate that estrogen treatment has a neuroprotective effect by attenuating expression of selective markers of apoptosis.
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收藏
页码:229 / 230
页数:2
相关论文
共 5 条
[1]   Neuroprotective effects of estrogens: potential mechanisms of action [J].
Green, PS ;
Simpkins, JW .
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 2000, 18 (4-5) :347-358
[2]   Estrogen as a neuroprotectant in stroke [J].
Hurn, PD ;
Macrae, IM .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2000, 20 (04) :631-652
[3]   Estrogen protects against global ischemia-induced neuronal death and prevents activation of apoptotic signaling cascades in the hippocampal CA1 [J].
Jover, T ;
Tanaka, H ;
Calderone, A ;
Oguro, K ;
Bennett, MVL ;
Etgen, AM ;
Zukin, RS .
JOURNAL OF NEUROSCIENCE, 2002, 22 (06) :2115-2124
[4]   Gender differences in acute CNS trauma and stroke: Neuroprotective effects of estrogen and progesterone [J].
Roof, RL ;
Hall, ED .
JOURNAL OF NEUROTRAUMA, 2000, 17 (05) :367-388
[5]   Estrogens: Trophic and protective factors in the adult brain [J].
Wise, PM ;
Dubal, DB ;
Wilson, ME ;
Rau, SW ;
Liu, Y .
FRONTIERS IN NEUROENDOCRINOLOGY, 2001, 22 (01) :33-66