Breast Cancer Before Age 40 Years

被引：526

作者：

Anders, Carey K. ^{[1
]}

Johnson, Rebecca ^{[2
]}

Litton, Jennifer ^{[3
]}

Phillips, Marianne ^{[4
]}

Bleyer, Archie ^{[5
]}

机构：

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[2] Seattle Childrens Hosp, Seattle, WA USA

[3] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[4] Princess Margaret Hosp Children, Perth, WA, Australia

[5] St Charles Hosp, Bend, OR USA

来源：

SEMINARS IN ONCOLOGY | 2009年 / 36卷 / 03期

关键词：

PREMENOPAUSAL WOMEN; ADJUVANT CHEMOTHERAPY; YOUNG-WOMEN; VITAMIN-D; FERTILITY PRESERVATION; CONSERVING THERAPY; RANDOMIZED-TRIAL; ZOLEDRONIC ACID; INCREASED RISK; STAGE-I;

D O I：

10.1053/j.seminoncol.2009.03.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Approximately 7% of women with breast cancer are diagnosed before the age of 40 years, and this disease accounts for more than 40% of all cancer in women in this age group. Survival rates are worse when compared to those in older women, and multivariate analysis has shown younger age to be an independent predictor of adverse outcome. Inherited syndromes, specifically BRCA1 and BRCA2, must be considered when developing treatment algorithms for younger women. Chemotherapy, endocrine, and local therapies have the potential to significantly impact both the physiologic health-including future fertility, premature menopause, and bone health-and the psychological health of young women as they face a diagnosis of breast cancer. © 2009.

引用

页码：237 / 249

页数：13

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