Distribution of adrenomedullin-containing perivascular nerves in the rat mesenteric artery

被引：25

作者：

Hobara, N

Nakamura, A

Ohtsuka, A

Narasaki, A

Shibata, K

Gomoita, Y

Kawasaki, H

机构：

[1] Okayama Univ, Grad Sch Nat Sci & Technol, Dept Clin Pharmaceut Sci, Okayama 7008530, Japan

[2] Okayama Univ, Grad Sch Med & Dent, Dept Human Morphol, Okayama 7008530, Japan

[3] Okayama Univ, Sch Med, Dept Hosp Pharm, Okayama 700, Japan

来源：

PEPTIDES | 2004年 / 25卷 / 04期

关键词：

adrenomedullin; perivascular nerve; rat mesenteric artery; calcitonin gene-related peptide; neuropeptide Y; capsaicin-sensitive nerve;

D O I：

10.1016/j.peptides.2004.02.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Distribution of adrenomedullin (AM)-containing perivascular nerve fibers was studied in rat mesenteric arteries. Many fibers containing AM-like immunoreactivity (LI) were observed in the adventitia. AM-LI fibers were abolished by cold storage denervation or capsaicin but not 6-hydroxydopamine. Double immunostainings showed colocalization of AM-LI with calcitonin gene-related peptide (CGRP)-LI. The dorsal root ganglia had many AM-positive cells and AM mRNA detected by RT-PCR. Electron microscopy study revealed high proportions of immunogold labeling for AM and colocalization of both AM-LI and CGRP-LI in unmyelinated nerve axons. These results suggest that AM-containing perivascular nerves are distributed in the rat mesenteric artery. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：589 / 599

页数：11

共 35 条

[1] Adrenomedullin inhibits neurotransmission of calcitonin gene-related peptide (CGRP)-containing vasodilator nerves in rat mesenteric resistance arteries [J].