ABCG2 -: a transporter for all seasons

被引：223

作者：

Sarkadi, B

Özvegy-Laczka, C

Német, K

Váradi, A

机构：

[1] Hungarian Acad Sci, Membrane Res Grp, Inst Haematol & Immunol, Natl Med Ctr, H-1113 Budapest, Hungary

[2] Hungarian Acad Sci, Inst Enzymol, H-1113 Budapest, Hungary

来源：

FEBS LETTERS | 2004年 / 567卷 / 01期

关键词：

ABCG2; multidrug transporter; xenobiotic transport; cancer drug resistance; stem cell regulation; polymorphic variant; gene therapy; hypoxic defense;

D O I：

10.1016/j.febslet.2004.03.123

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human ABCG2 (ABCP/MXR/BCRP) protein is a recently recognized ABC half-transporter, which forms homodimers in the plasma membrane and actively extruses a wide variety of chemically unrelated compounds from the cells. This protein protects our cells and tissues against various xenobiotics, with a crucial role in the intestine, liver, placenta, and the blood-brain barrierr. Moreover, ABCG2 seems to have a key function in stem cell protection/regulation, and also in hypoxic defense mechanisms. Widely occuring single nucleotide polymorphisms in ABCG2 may affect absorption and distribution, altering the effectiveness and toxicity of drugs in large populations. At the clinics, overexpression of ABCG2 in tumor cells confers cancer multidrug resistance to a variety of newly developed anticancer agents. On the other hand, specific substrate mutants of ABCG2 are advocated for use as selectable markers in stem-cell based gene therapy. (C) 2004 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：116 / 120

页数：5

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