Autophagy, a key mechanism of oncogenesis and resistance in leukemia

被引：160

作者：

Auberger, Patrick

Puissant, Alexandre ^{[1
,2
]}

机构：

[1] Univ Cote Azur, Ctr Mediterraneen Med Mol, INSERM U1065, Nice, France

[2] Hop St Louis, Inst Univ Hematol, INSERM, Unite Mixte Rech 944, Paris, France

来源：

BLOOD | 2017年 / 129卷 / 05期

关键词：

BCR-ABL; CELL-DEATH; NEUTROPHIL DIFFERENTIATION; CYTOPROTECTIVE AUTOPHAGY; TARGETING AUTOPHAGY; THERAPEUTIC TARGET; RAD001; EVEROLIMUS; ARSENIC TRIOXIDE; DRUG-RESISTANCE; INHIBITION;

D O I：

10.1182/blood-2016-07-692707

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Autophagy is a lysosomal pathway involved in degradation of intracellular material. It appears as an adaptation mechanism that is essential for cellular homeostasis in response to various stress conditions. Over the past decade, many studies have linked alteration of autophagy with cancer initiation and progression, autoimmune, inflammatory, metabolic, and degenerative diseases. This review highlights recent findings on the impact of autophagy on leukemic transformation of normal hematopoietic stem cells and summarizes its role on leukemic cell response to chemotherapy.

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收藏

页码：547 / 552

页数：6

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