Lipid a structures containing novel lipid moieties: Synthesis and adjuvant properties

被引：30

作者：

Jiang, ZH ^{[1
]}

Bach, MV ^{[1
]}

Budzynski, WA ^{[1
]}

Krantz, MJ ^{[1
]}

Koganty, RR ^{[1
]}

Longenecker, BM ^{[1
]}

机构：

[1] Biomira Inc, Edmonton, AB T6N 1H1, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 16期

关键词：

D O I：

10.1016/S0960-894X(02)00362-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Structurally well-defined immune stimulatory molecules are important components of new generation molecular vaccines. In this paper, the design and synthesis of two lipid A analogues containing an unnatural tri-lipid acyl group are described. In a totally synthetic liposomal vaccine system, these re-designed lipid A analogues demonstrate potent immune stimulatory properties including antigen specific T-cell activation. (C) 2002 Elsevier Science Ltd. All rights reserved.

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收藏

页码：2193 / 2196

页数：4

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