Topoisomerase II checkpoints -: Universal mechanisms that regulate mitosis

被引：42

作者：

Clarke, Duncan J.

Vas, Amit C.

Andrews, Catherine A.

Diaz-Martinez, Laura A.

Gimenez-Abian, Juan F.

机构：

[1] Univ Minnesota, Sch Med, Dept Genet Cell Biol & Dev, Minneapolis, MN 55455 USA

[2] CSIC, Ctr Invest Biol, Madrid, Spain

来源：

CELL CYCLE | 2006年 / 5卷 / 17期

关键词：

Topoisomerase II; Topo II; Top2; checkpoint; decatenation; catenation; Mad2; Pds1; G(2); anaphase;

D O I：

10.4161/cc.5.17.3200

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Checkpoint controls confer order to the cell cycle and help prevent genome instability. Here we discuss the Topoisomerase II (Decatenation) Checkpoint which functions to regulate mitotic progression so that chromosomes can be efficiently condensed in prophase and can be segregated with high fidelity in anaphase.

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页码：1925 / 1928

页数：4

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