The cardiac endothelium: Cardioactive mediators

被引:38
作者
Shah, AM
GrocottMason, RM
Pepper, CB
Mebazaa, A
Henderson, AH
Lewis, MJ
Paulus, WJ
机构
[1] UNIV WALES COLL MED,DEPT THERAPEUT & PHARMACOL,CARDIOVASC SCI RES GRP,CARDIFF CF4 4XN,S GLAM,WALES
[2] ONZE LIEVE VROUW HOSP,CTR CARDIOVASC,AALST,BELGIUM
基金
英国医学研究理事会;
关键词
D O I
10.1016/S0033-0620(96)80005-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Endothelial cells within the heart release a number of substances that modulate myocardial contractile function. These agents include nitric oxide, endothelin, prostanoids, adenylpurines, and other substances that have so far been characterized only in bioassay studies. A notable feature of many of these agents is that they influence contractile behavior predominantly by modifying cardiac myofilament properties rather than altering cytosolic Ca2+ transients. A consequence of this subcellular action is often a disproportionate effect on myocardial relaxation and diastolic tone. The paracrine modulation of cardiac myocyte function by endothelial cell factors is likely to be an important mechanism contributing to the overall regulation of cardiac contractile function, both physiologically and in pathological states.
引用
收藏
页码:263 / 284
页数:22
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