Performing functional magnetic resonance imaging in patients with Parkinson's disease treated with deep brain stimulation

被引:37
作者
Arantes, Paula R.
Cardoso, Ellison F.
Barreiros, Maria A.
Teixeira, Manoel J.
Goncalves, Marcia R.
Barbosa, Egberto R.
Sukwinder, Sukhi Shergill
Leite, Claudia C.
Amaro, Edson, Jr.
机构
[1] Univ Sao Paulo, Sch Med, Dept Radiol, Sao Paulo, Brazil
[2] Univ Sao Paulo, Sch Med, Dept Neurosurg, Sao Paulo, Brazil
[3] Univ Sao Paulo, Sch Med, Dept Neurol, Sao Paulo, Brazil
[4] Kings Coll London, IoP, Dept Psychol Med, London WC2R 2LS, England
关键词
functional magnetic resonance imaging; Parkinson's disease; deep brain stimulation; block design; event-related design; brain activation; subthalamic nucleus;
D O I
10.1002/mds.20912
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Deep brain stimulation (DBS) is a relatively novel treatment in advanced Parkinson's disease (PD). Functional magnetic resonance imaging (fMRI) is a useful technique for examining the effects of DBS both within the basal ganglia and its cortical connectivity. There are technical difficulties in imaging patients with PD, and the DBS itself can generate image artifacts. We describe aspects related to optimizing the fMRI acquisition parameters in patients with DBS and the results of sensorimotor activation tasks performed by four PD patients during hand, foot, and tongue movements, both before and after DBS implant. Provided that all safety conditions are followed, it is possible to perform fMRI in patients with PD and DBS. The standard DBS surgical procedure has to be slightly modified in order to reduce image artifacts. The event-related design provided increased power to detect sensorimotor cortex and basal ganglia activation. (C) 2006 Movement Disorder Society.
引用
收藏
页码:1154 / 1162
页数:9
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