Rapid detection of fibrinogen and fibrin degradation products using a smart QCM-sensor

被引：29

作者：

Aizawa, H

Kurosawa, S ^{[1
]}

Tozuka, M

Park, JW

Kobayashi, K

机构：

[1] Natl Inst AIST, Tsukuba, Ibaraki 3058565, Japan

[2] NEDO, Tokyo 1706028, Japan

[3] CNRS, IPCMS, F-67034 Strasbourg 2, France

[4] Musashi Inst Technol, Tokyo 1588557, Japan

[5] Univ Tokyo, Tokyo 1138656, Japan

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2004年 / 101卷 / 1-2期

关键词：

immumosensor; quartz crystal microbalance (QCM); fibrinogen and fibrin degradation products (FDP); immunized latex; smart QCM-sensor;

D O I：

10.1016/j.snb.2004.02.057

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We have developed a rapid immunosensor for fibrinogen and fibrin degradation products (FDP) that combines a quartz crystal microbalance (QCM) with the agglutination reaction of anti-FDP antibody immunized latex beads. We measured FDP concentration successfully in human serum within 10 min with a smart QCM-sensor. The detection range of the smart QCM-sensor is covered with screening concentration of FDP in serum (less than 10 mug ml(-1) of FDP). (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：150 / 154

页数：5

共 27 条

[1] Conventional detection method of fibrinogen and fibrin degradation products using latex piezoelectric immunoassay [J].