Constant supersaturation control of antisolvent-addition batch crystallization

被引：23

作者：

Nonoyama, Nobuaki ^{[1
]}

Hanaki, Keigo ^{[1
]}

Yabuki, Yasuaki ^{[1
]}

机构：

[1] Banyu Pharmaceut Co Ltd, Proc Res, Aichi 4440858, Japan

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2006年 / 10卷 / 04期

关键词：

D O I：

10.1021/op0600052

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We have developed a simple method to design antisolvent-addition crystallization by using a numerical simulation. To design the reasonable conditions, e. g. the profile of antisolvent addition, seed loading, and minimum time cycle, a numerical simulation was applied using kinetic parameters obtained from experiments. ReactIR was used for on-line monitoring, which enabled the concentration, supersaturation, and growth rate to be monitored throughout the crystallization process. This model takes into account only growth and ignores nucleation, agglomeration, and breakage. The results of the numerical simulations agreed well with the corresponding experimental results and assisted in the design of a suitable crystallization process.

引用

页码：727 / 732

页数：6

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