Acute treatment of hypertension increases infarct sizes in spontaneously hypertensive rats

被引：15

作者：

Harms, H

Wiegand, F

Megow, D

Prass, K

Einhäupl, KM

Dirnagl, U ^{[1
]}

机构：

[1] Humboldt Univ, Charite, Dept Neurol, D-10098 Berlin, Germany

[2] Univ Essen Gesamthsch, Dept Neurol, D-4300 Essen, Germany

来源：

NEUROREPORT | 2000年 / 11卷 / 02期

关键词：

blood pressure; dihydralazine; focal cerebral ischemia; stroke;

D O I：

10.1097/00001756-200002070-00027

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We studied the effect of dihydralazine treatment of hypertension in spontaneously hypertensive stroke-prone rats in a model of permanent focal cerebral ischemia (stroke). After occlusion of the middle cerebral artery systemic arterial pressure (SAP) was lowered with a computer controlled infusion device from 163 to 135 or 117 mmHg for 24 h. In the control group SAP was not manipulated. Reduction of SAP to normotension (117 mmHg) significantly worsened outcome and increased infarct volume measured 7 days after induction of ischemia, whereas a mild reduction of SAP (to 137 mmHg) had no statistically significant effect on outcome or infarct volume. We conclude that pharmacological treatment of hypertension may negatively affect neurological outcome and infarct volume in a rat stroke model. NeuroReport 11:355-359 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：355 / 359

页数：5

共 24 条

[1] CEREBRAL BLOOD-FLOW DURING DIHYDRALAZINE-INDUCED HYPOTENSION IN HYPERTENSIVE RATS [J].