N-(sulfonamido)alkyl[tetrahydro-1H-benzo[e]indol-2-yl] amines:: Potent antagonists of human neuropeptide YY5 receptor

被引：22

作者：

McNally, JJ

Youngman, MA

Lovenberg, TW

Nepomuceno, DH

Wilson, SJ

Dax, SL

机构：

[1] RW Johnson Pharmaceut Res Inst, Drug Discovery, Spring House, PA 19477 USA

[2] RW Johnson Pharmaceut Res Inst, Drug Discovery, San Diego, CA 92121 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(99)00676-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[3a,4,5,9b-Tetrahydro-1H-benzo[e]indol-2-yl]amines were prepared via reductive amination and concomitant cyclization of alpha-cyanomethyl-beta-aminotetralins. N-acylation with Omega-sulfonamido-carboxylic acids and subsequent reduction afforded a series of N-(sulfonamido)alkyl[tetrahydro-1H-benzo[e]indol-2-yl]amines, which bound to the human neuropeptide Y Y5 receptor with nanomolar affinity. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：213 / 216

页数：4

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