Effect of pH on the in vitro activities of amphotericin B, itraconazole, and flucytosine against Aspergillus isolates

被引：31

作者：

Te Dorsthorst, DTA

Mouton, JW

van den Beukel, CJP

van der Lee, HAL

Meis, JFGM

Verweij, PE ^{[1
]}

机构：

[1] Catholic Univ Nijmegen, Med Ctr, Dept Med Microbiol, NL-6500 HB Nijmegen, Netherlands

[2] Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, NL-6500 HB Nijmegen, Netherlands

[3] Univ Med Ctr, Dept Med Microbiol, Nijmegen, Netherlands

[4] Univ Nijmegen, Ctr Infect Dis, Nijmegen, Netherlands

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 08期

关键词：

D O I：

10.1128/AAC.48.8.3147-3150.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The in vitro susceptibilities of 21 Aspergillus isolates were tested against three antifungal agents in RPMI 1640 and yeast nitrogen base at pH 5.0 and 7.0 by a broth microdilution format of the NCCLS method. The MICs of amphotericin B and itraconazole were higher, while those of flucytosine were lower, at pH 5.0 than at pH 7.0. The poor correlation between in vitro results and clinical outcome could be due to a difference in pH between the in vitro susceptibility test and at the site of infection.

引用

页码：3147 / 3150

页数：4

共 9 条

[1] ESTABLISHMENT OF AN EXPERIMENTAL-MODEL OF A STAPHYLOCOCCUS-AUREUS ABSCESS IN MICE BY USE OF DEXTRAN AND GELATIN MICROCARRIERS [J].