Prophylactic effect of glyceryl trinitrate on post-endoscopic retrograde cholangiopancreatography pancreatitis: A randomized placebo-controlled trial

被引：29

作者：

Hao, Jian-Yu ^{[1
]}

Wu, Dong-Fang ^{[1
]}

Wang, Yue-Zeng ^{[1
]}

Gao, Ying-Xin ^{[1
]}

Lang, Hai-Po ^{[1
]}

Zhou, Wei-Zhen ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Chaoyang Hosp, Dept Digest, Beijing 100020, Peoples R China

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2009年 / 15卷 / 03期

关键词：

Glyceryl trinitrate; Cholangiopancreatography; Endoscopic retrograde; Pancreatitis; ERCP PANCREATITIS; SPHINCTEROTOMY; COMPLICATIONS; RISK;

D O I：

10.3748/wjg.15.366

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

AIM: To examine the prophylactic effect of glyceryl trinitrate on post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis and hyperamylasemia. METHODS: Patients scheduled for ERCP were randomly divided into study group and placebo group. Patients in study group and placebo group were treated with 5 mg glyceryl trinitrate and 100 mg vitamin C, respectively, 5 min before endoscopic maneuvers. RESULTS: A total of 74 patients were enrolled in the final analysis. Post-ERCP pancreatitis occurred in 3 patients (7.9%) of the study group and 9 patients (25%) in the placebo group (P = 0.012). Hyperamylasemia occurred in 8 patients of the study group (21.1%) and 13 patients (36.1%) of the placebo group (P = 0.037). CONCLUSION: Glyceryl trinitrate before ERCP can effectively prevent post-ERCP and hyperamylasemia. (C) 2009 The WJG Press and Baishideng. All rights reserved.

引用

页码：366 / 368

页数：3

共 11 条

[1]

Gabexate or somatostatin administration before ERCP in patients at high risk for post-ERCP pancreatitis: a multicenter, placebo-controlled, randomized clinical trial [J].