Influence of polyethylene terephthalate on the release of growth factors by human endothelial cells

被引:3
作者
Cenni, E [1 ]
Verri, E
Granchi, D
Gamberini, S
Corradini, A
Di Leo, A
Montanaro, L
Pizzoferrato, A
机构
[1] Ist Ortopedici Rizzoli, Lab Biocompatibil Res Implant Mat, Bologna, Italy
[2] Policlin S Orsola, Ist Fisiopatol Riproduz, I-40138 Bologna, Italy
关键词
polyethylene terephthalate; endothelial cell; platelet derived growth factor; fibroblast growth factor;
D O I
10.1163/156856299X00513
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The influence of polyethylene terephthalate (PET) on the release of platelet derived growth factor AB (PDGF-AB) and basic fibroblast growth factor (bFGF) by in vitro cultured human endothelial cells was assessed by enzyme immunoassay. No significant differences were observed in the production of PDGF-AB with respect to the negative control cultures. A significant increase was observed in the production of bFGF after 48 and 72 h with respect to the negative control cultures. It can be concluded that PET may induce an increase in the production of basic FGF in endothelial cells.
引用
收藏
页码:891 / 900
页数:10
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