Angiotensin-converting enzyme genotype is associated with Alzheimer disease in the Japanese population

被引：67

作者：

Hu, J

Miyatake, F

Aizu, Y

Nakagawa, H

Nakamura, S

Tamaoka, A

Takahash, R

Urakami, K

Shoji, M

机构：

[1] BLM Inc, R&D Ctr, Kawagoe, Saitama 3501101, Japan

[2] Hiroshima Univ, Dept Internal Med 3, Minami Ku, Hiroshima 7348551, Japan

[3] Univ Tsukuba, Inst Clin Med, Dept Neurol, Tsukuba, Ibaraki 3058575, Japan

[4] Tokyo Metropolitan Inst Neurosci, Dept Neurol, Fuchu, Tokyo 1838526, Japan

[5] Tottori Univ, Fac Med, Div Neurol, Inst Neurol Sci, Yonago, Tottori 6838504, Japan

来源：

NEUROSCIENCE LETTERS | 1999年 / 277卷 / 01期

关键词：

angiotensin-converting enzyme; genotype; risk factor; Alzheimer disease;

D O I：

10.1016/S0304-3940(99)00827-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We compared the distribution of an insertion (I)/deletion (D) polymorphism of the gene coding for the angiotensin-converting enzyme (ACE) in 133 Japanese sporadic Alzheimer disease (AD) patients with 257 controls. The association between AD and ACE genotypes or alleles was found to be significant. The frequency of II genotypes was 1.4 times higher in AD than controls, while that of DD genotypes was only 0.4 times as high. The altered distribution of ACE alleles in patients with AD appeared to be independent of apolipoprotein E. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：65 / 67

页数：3

共 20 条

[1] Angiotensin-converting enzyme gene polymorphism in systemic hypertension
Abbud, ZA
Wilson, AC
Cosgrove, NM
Kostis, JB
[J]. AMERICAN JOURNAL OF CARDIOLOGY, 1998, 81 (02) : 244 - 246
[2] Excitatory action of angiotensins II and IV on hippocampal neuronal activity in urethane anesthetized rats
Albrecht, D
Broser, M
Kruger, H
[J]. REGULATORY PEPTIDES, 1997, 70 (2-3) : 105 - 109
[3] HIXSON JE, 1990, J LIPID RES, V31, P545
[4] Impaired blood-brain barrier function in angiotensinogen-deficient mice
Kakinuma, Y
Hama, H
Sugiyama, F
Yagami, K
Goto, K
Murakami, K
Fukamizu, A
[J]. NATURE MEDICINE, 1998, 4 (09) : 1078 - 1080
[5] Anti-apoptotic action of angiotensin fragments to neuronal cells from angiotensinogen knock-out mice
Kakinuma, Y
Hama, H
Sugiyama, F
Goto, K
Murakami, K
Fukamizu, A
[J]. NEUROSCIENCE LETTERS, 1997, 232 (03) : 167 - 170
[6] Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease
Kehoe, PG
Russ, C
McIlroy, S
Williams, H
Holmans, P
Holmes, C
Liolitsa, D
Vahidassr, D
Powell, J
McGleenon, B
Liddell, M
Plomin, R
Dynan, K
Williams, N
Neal, J
Cairns, NJ
Wilcock, G
Passmore, P
Lovestone, S
Williams, J
Owen, MJ
[J]. NATURE GENETICS, 1999, 21 (01) : 71 - 72
[7] Angiotensin II- and IV-induced changes in cerebral blood flow roles of AT(1) AT(2), and AT(4) receptor subtypes
Kramar, EA
Harding, JW
Wright, JW
[J]. REGULATORY PEPTIDES, 1997, 68 (02) : 131 - 138
[8] Relation between severity of coronary artery disease, left ventricular function, and myocardial infarction and influence of the ACE I/D gene polymorphism
Ledru, F
Blanchard, D
Battaglia, S
Jeunemaitre, X
Courbon, D
Guize, L
Guermonprez, JL
Ducimetière, P
Diébold, B
[J]. AMERICAN JOURNAL OF CARDIOLOGY, 1998, 82 (02) : 160 - 165
[9] MCKHANN G, 1984, NEUROLOGY, V34, P939, DOI 10.1212/WNL.34.7.939
[10] APOE-EPSILON-4 AND EARLY-ONSET ALZHEIMERS
OKUIZUMI, K
ONODERA, O
TANAKA, H
KOBAYASHI, H
TSUJI, S
TAKAHASHI, H
OYANAGI, K
SEKI, K
TANAKA, M
NARUSE, S
MIYATAKE, T
MIZUSAWA, H
KANAZAWA, I
[J]. NATURE GENETICS, 1994, 7 (01) : 10 - 11

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