Clinical and laboratory work-up of patients with neutrophil shortage or dysfunction

被引：31

作者：

Kuijpers, TW

Weening, RS

Roos, D

机构：

[1] Netherlands Red Cross, Dept Expt Immuno Hematol, Cent Lab, NL-1066 CX Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Emma Childrens Hosp, NL-1105 AZ Amsterdam, Netherlands

[3] Univ Amsterdam, Acad Med Ctr, Expt & Clin Immunol Lab, NL-1105 AZ Amsterdam, Netherlands

来源：

JOURNAL OF IMMUNOLOGICAL METHODS | 1999年 / 232卷 / 1-2期

关键词：

neutrophils; neutropenia; neutrophil dysfunctions; neonatal alloimmune neutropenia (NAINP); alloimmune neutropenia (AINP); granulocyte colony-stimulating factor (G-CSF); chemotaxis; adherence; phagocytosis; degranulation; respiratory burst; reticular dysgenesis; Kostmann syndrome; cyclic neutropenia; benign neutropenia of childhood; Shwachman-Diamond syndrome; glycogen storage disease type 1b; leukocyte adhesion deficiency (LAD); hyper-IgE syndrome; neutrophil actin dysfunction (NAD); rac-2; deficiency; Papillon-Lefevre syndrome; chronic granulomatous disease (GCD); myeloperoxidase (MPO) deficiency;

D O I：

10.1016/S0022-1759(99)00178-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Neutrophils have a crucial function in the defense against bacteria and fungi. Indeed, during chronic, severe neutropenia and in case of severe neutrophil dysfunctions, the patients may suffer recurrent and sometimes life-threatening infections. This article describes the clinical symptoms, the theory behind the antimicrobial systems of neutrophils, the methods to diagnose the various aberrations, and the possibilities for treating these patients. A few of the most common causes of neutropenia and neutrophil dysfunctions are described in detail, including recent genetic information regarding the cause of these diseases. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：211 / 229

页数：19

共 34 条

[1]

Identification of the homologous beige and Chediak-Higashi syndrome genes [J].