HMB45 negative spindle cell malignant melanoma

被引：28

作者：

Skelton, HG

Maceira, J

Smith, KJ

McCarthy, WF

Lupton, GP

Graham, JH

机构：

[1] ARMED FORCES INST PATHOL, DEPT DERMATOPATHOL, WASHINGTON, DC 20306 USA

[2] NATL NAVAL MED CTR, DEPT DERMATOL, BETHESDA, MD USA

[3] UNIFORMED SERV UNIV HLTH SCI, DEPT SURG, BETHESDA, MD 20814 USA

[4] UNIFORMED SERV UNIV HLTH SCI, RIO DE JANEIRO, BRAZIL

[5] UNIFORMED SERV UNIV HLTH SCI, LA JOLLA, CA USA

来源：

AMERICAN JOURNAL OF DERMATOPATHOLOGY | 1997年 / 19卷 / 06期

关键词：

desmoplastic malignant melanoma; spindle cell malignant melanoma; HMB45; premelanosomes;

D O I：

10.1097/00000372-199712000-00005

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Desmoplastic malignant melanoma (DMM) and spindle cell malignant melanoma (SCMM) form a continuum without a discrete separation. One feature characteristic of DMM is a negative reaction for HMB45, a marker for premelanosomes. Fifty-six cases of SCMM were stained with HMB45. The clinical features, histologic features, and survival data for HMB45(+) and HMB45(-) SCMM were compared. Thirty cases were HMB45(-), and 26 were HMB45(+). In the HMB45(-) cases, there was a 1.4:1 ratio of males to females, and in the HMB45(+) cases the ratio was 1:1.5. Only 12.9% of the HMB45(-) cases occurred on the trunk compared with 40% of the HMB45(+) cases. The average ages for the HMB45(-) and the HMB45(+) cases were 65.6 and 61 years, respectively. Follow-up was obtained on 22 cases: 11 HMB45(-) and 11 HMB45(+). Of the 11 HMB45(-) cases, four had a 5-year disease-free survival. Of the 11 HMB45(+) cases, only one had a 5-year disease free survival. HMB45(-) SCMM appear to have a less aggressive biologic potential than HMB45(+) SCMM.

引用

页码：580 / 584

页数：5

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