Role of tumor necrosis factor alpha in pathogenesis of pneumococcal pneumonia in mice

被引：125

作者：

Takashima, K ^{[1
]}

Tateda, K ^{[1
]}

Matsumoto, T ^{[1
]}

Iizawa, Y ^{[1
]}

Nakao, M ^{[1
]}

Yamaguchi, K ^{[1
]}

机构：

[1] TOHO UNIV, SCH MED, DEPT MICROBIOL, TOKYO, JAPAN

来源：

INFECTION AND IMMUNITY | 1997年 / 65卷 / 01期

关键词：

STREPTOCOCCUS-PNEUMONIAE; NEUTROPHILS; MENINGITIS; STIMULATION; ENDOTHELIUM; GENERATION; INFECTION; COMMUNITY; CYTOKINES; ETIOLOGY;

D O I：

10.1128/IAI.65.1.257-260.1997

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The production and role of tumor necrosis factor alpha (TNF-alpha) in pneumococcal pneumonia were investigated in a mouse pneumonia model, When approximately 10(6) CFU of Streptococcus pneumoniae TUM19 were used to inoculate CBA/J mice intranasally, TNF-alpha levels in the lungs and serum began to increase from 1 and 3 days after infection, respectively, concomitantly with the increase in bacterial counts in the lungs, Anti-TNF-alpha antibody accelerated bacterial proliferation in the blood and the death of the mice. Although serum levels of not affected by the anti-TNF-alpha antibody treatment, neutrophil counts in the blood were decreased by the treatment. These results suggest that TNF-alpha produced in the course of pneumococcal pneumonia prevents bacteremia by increasing the number of neutrophils in the blood.

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页码：257 / 260

页数：4

相关论文

共 24 条

[1] INVIVO EFFICACY OF A NEW FLUOROQUINOLONE, SPARFLOXACIN, AGAINST PENICILLIN-SUSCEPTIBLE AND PENICILLIN-RESISTANT AND MULTIRESISTANT STRAINS OF STREPTOCOCCUS-PNEUMONIAE IN A MOUSE MODEL OF PNEUMONIA [J].

AZOULAYDUPUIS, E ;

VALLEE, E ;

VEBER, B ;

BEDOS, JP ;

BAUCHET, J ;

POCIDALO, JJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (12) :2698-2703

[2] TUMOR-NECROSIS-FACTOR TYPE-ALPHA STIMULATES HUMAN-ENDOTHELIAL CELLS TO PRODUCE GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR [J].

BROUDY, VC ;

KAUSHANSKY, K ;

SEGAL, GM ;

HARLAN, JM ;

ADAMSON, JW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (19) :7467-7471

[3] A QUANTITATIVE-ANALYSIS OF THE INTERACTIONS OF ANTI-PNEUMOCOCCAL ANTIBODY AND COMPLEMENT IN EXPERIMENTAL PNEUMOCOCCAL BACTEREMIA [J].

BROWN, EJ ;

HOSEA, SW ;

HAMMER, CH ;

BURCH, CG ;

FRANK, MM .

JOURNAL OF CLINICAL INVESTIGATION, 1982, 69 (01) :85-98

[4] MECHANISMS OF HOST DEFENSE AGAINST INFECTION WITH STREPTOCOCCUS-PNEUMONIAE [J].

BRUYN, GAW ;

ZEGERS, BJM ;

VANFURTH, R .

CLINICAL INFECTIOUS DISEASES, 1992, 14 (01) :251-262

[5] EXPERIMENTAL ELIMINATION OF TUMOR-NECROSIS-FACTOR IN LOW-DOSE ENDOTOXIN MODELS HAS VARIABLE EFFECTS ON SURVIVAL [J].

FRANKS, AK ;

KUJAWA, KI ;

YAFFE, LJ .

INFECTION AND IMMUNITY, 1991, 59 (08) :2609-2614

[6] THE LIMITED ROLE OF PNEUMOLYSIN IN THE PATHOGENESIS OF PNEUMOCOCCAL MENINGITIS [J].

FRIEDLAND, IR ;

PARIS, MM ;

HICKEY, S ;

SHELTON, S ;

OLSEN, K ;

PATON, JC ;

MCCRACKEN, GH .

JOURNAL OF INFECTIOUS DISEASES, 1995, 172 (03) :805-809

[7] STIMULATION OF THE ADHERENCE OF NEUTROPHILS TO UMBILICAL VEIN ENDOTHELIUM BY HUMAN RECOMBINANT TUMOR-NECROSIS-FACTOR [J].

GAMBLE, JR ;

HARLAN, JM ;

KLEBANOFF, SJ ;

VADAS, MA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (24) :8667-8671

[8] TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA) IN CEREBROSPINAL-FLUID FROM PATIENTS WITH MENINGITIS OF DIFFERENT ETIOLOGIES - HIGH-LEVELS OF TNF-ALPHA INDICATE BACTERIAL-MENINGITIS [J].

GLIMAKER, M ;

KRAGSBJERG, P ;

FORSGREN, M ;

OLCEN, P .

JOURNAL OF INFECTIOUS DISEASES, 1993, 167 (04) :882-889

[9] THE ROLE OF OPSONINS IN RECOVERY FROM EXPERIMENTAL PNEUMOCOCCAL PNEUMONIA [J].

GUCKIAN, JC ;

CHRISTENSEN, GD ;

FINE, DP .

JOURNAL OF INFECTIOUS DISEASES, 1980, 142 (02) :175-190

[10]

HEUTMANN D, 1994, INFECT IMMUN, V62, P2715