Dendritic cells, BAFF, and APRIL: Innate players in adaptive antibody responses

被引：151

作者：

MacLennan, ICM ^{[1
]}

Vinuesa, CG

机构：

[1] Univ Birmingham, MRC, Ctr Immune Regulat, Birmingham B15 2TT, W Midlands, England

[2] Australian Natl Univ, John Curtin Sch Med Res, Med Genome Ctr, Canberra, ACT 2601, Australia

来源：

IMMUNITY | 2002年 / 17卷 / 03期

关键词：

D O I：

10.1016/S1074-7613(02)00398-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The first antibody produced in bacterial or viral infection results from B cell growth as plasmablasts. Dendritic cell-derived TNF-family ligands APRIL and/or BAFF plasmablast survival and differentiation to plasma cells. Expression of these ligands by dendritic cells is promoted by innate immune signals that can convert subliminal B cell activation to a productive response. While this may be lifesaving in the face of infection, it can predispose to autoantibody production.

引用

页码：235 / 238

页数：4

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